Pros
Technically stimulating, big spenders though not necessarily on salaries, very nice location on shoreline, big-time scientists and thinkers, sweet bonuses, company-provided shuttle service from most Bay Area cities.
Kontras
Meetings overkill, over-emphasis on PhD as an indicator for competency, out-of-control spending on food and events produces too much waste, middle-managers are technically superior but often lacking in soft-skills and years of true managerial experience, recognition often based on conference-room capability rather than on-the-job capability and delivery of results, Executive level and HR focused on protection of company reputation over employee protection, need to stop blaming Roche for everything gone wrong considering there are still many Genentech executives and directors holding their jobs, post merger.